ARTICLE PUBLISHED IN AUGUST 2025 BY JAVI JAMES. ALL RIGHTS RESERVED. ISSN S/N.​

First of all, note that serotonin and dopamine are key neurotransmitters for the central nervous system. Each synapse (neuronal connection) releases serotonin, and then the same system recaptures part of that neurotransmitter, as this naturally optimizes functions. This is what science manipulates in such a meticulous way with medications, which of course impacts dopaminergic function and the central nervous system.

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With that in mind, to understand the physical logic behind the use of psilocybin and its therapeutic application, I will first clarify certain technical aspects. I have reviewed studies and articles published in scientific journals, such as this one; https://www.nature.com/articles/npp2009233, in which exogenous neuromodulators (medications) are used to treat stress and anxiety, and I have noticed that the principle used is to inhibit the reuptake of serotonin during the synapse, thus hoping for a better and more fluid neuronal response. Eventually they achieve this, because the results show that enhancing 5-HT (serotonin) neurotransmission decreases sensitivity to negative feedback and increases sensitivity to reward (positive feedback), while reducing it has the opposite effect. However, "this modulation must be adequate," because an exaggeration in either direction is unfavorable, that is, it cannot be inhibited too much or too little, and that is where the adjustment with the type of medication and dosage begins. The side effects are extensive and alter biological functions to varying degrees, since the aforementioned reuptake would be counterproductive for amino acid production, and physiological dynamics would suffer cascading alterations. So far, the use of neuromodulators seems more or less positive, but the nature of the manipulation they employ in their trials is generally biased and does not consider all the neurophysiological aspects that should be taken into account, at least in my opinion, and I will now explain why.​

The studies have a biased approach because they attempt to correct serotonergic function exogenously by manipulating bioavailable serotonin, thus invasively modifying the aforementioned neurofunctionality and physiological dynamics. And of course, by assuming that serotonin is metabolized solely from the amino acid tryptophan, it's assumed that this amino acid isn't generated by a completely endogenous process; that is, that humans don't produce it themselves but rather incorporate it only through diet. While this is correct, tryptophan isn't the best 5-HT agonist; in other words, it's not the most efficient way to produce serotonin. The most efficient form of serotonergic production and function is closely linked to the function of the pineal gland, the hormone melatonin, and DMT, but this hasn't been proven, or hasn't been published—of course, I may also be unaware of it. Many scientists accept this as a possibility, I suppose others deny it, and there will be those who conceal it. In short, the treatments focus on modulating the connections based on existing serotonin, counteracting the neurofunctional processes that stimulate the overproduction of melatonin (True Yoga). To reiterate, what I mean is that, with yogic discipline, we can use more DMT (endogenous) than tryptophan (exogenous), thereby increasing neuromotor autonomy and homeostasis (balance).

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So, let's be clear: the least efficient pathway for 5-HT production is through the metabolism of the amino acid tryptophan, which is obtained solely from food. This amino acid needs to be absorbed in the intestine, competing with others, which means our system can't absorb enough. Furthermore, it must also cross the blood-brain barrier to reach the brain. On the other hand, it's often said that the nine essential amino acids, including tryptophan, are not produced by humans and must be obtained exogenously. This is only partly true, because, as I've already mentioned, the exogenous pathway isn't the only one, and it's not the most efficient. The primary pathway is through melatonin and its metabolism into dimethyltryptamine (DMT). DMT should be the main 5-HT agonist, followed by tryptophan, but it turns out that achieving proper pineal gland function requires a great deal of discipline. Because, I reiterate, melatonin is a secretion of the aforementioned gland, and the function of this hormone is always related to the regulation of the circadian rhythm (sleep), but "its metabolism to DMT is not discussed," because according to some, such a thing doesn't exist. Denying this is the worst mistake in science. For some, this is already obvious, as is my case, since without that function I couldn't provide my therapies.

If you truly understand what I'm saying, you can see that common nutritional concepts are also biased and highly relative, since they focus on food as the primary method of obtaining amino acids, proteins, and carbohydrates. This doesn't mean that nutrition is entirely false, because this absorption from food does occur, but nutrition is based on a flawed foundation. This is because humans themselves can readily generate essential amino acids from DMT, which, through a cascade effect, are then converted into proteins and carbohydrates.

en converted into proteins and carbohydrates.​

Food poisons us, to a greater or lesser extent. There are foods with very low toxicity, but incorporating substances into our bodies implies, to a certain extent, poisoning. In fact, oxygen is also poisoning, because an excess of it leads to alkalosis, an acid-base imbalance. Of course, oxidation is part of the cellular cycle, and the less toxic the substance that enters us (quantity/quality), the fewer free radicals (harmful waste) there are to eliminate. Excesses lead to severe intoxication, and excess is not just a quantitative issue, but a frequency issue, without disregarding the qualitative factor (food quality). Food addiction makes us sick, regardless of the food. Prolonged fasting detoxifies because it gives the system space to reestablish itself. So, note that the balance is between hunger and illness. If we detoxify progressively, we can go days and days without eating. We don't need it, but it's part of our instinct, and it's good to integrate it, but it must be done autonomously. Electrical impulses (EGO) should not control our responses, since this lack of autonomy reflects anxiety, and it's not good to eat out of anxiety. Food must be absorbed through a subtle response, and by our own, clear decision. So, from now on, I suggest you eat very slowly. Observe, discern, decide.

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At this point, I can already refer to autonomy and the pineal gland. Many foods are designed to calcify this gland, and if we don't stimulate it, it atrophies. Pineal means "sacred antenna" because it modulates the signal to synchronize with our original genetic code. It is the third movement of the key, or Kybalion. Once the three secret movements are completed, neurofunctional processes toward superconsciousness are activated, and they are unique to each person. Melatonin is the hormone that regulates the circadian rhythm through the parasympathetic system (vagus nerve). Briefly, melatonin is metabolized into dimethyltryptamine, and many scientists know this by deduction; others are skeptical, but as I mentioned earlier, no official demonstration has been proposed, either yes or no.